MovDisordV3, Main, Exploration, bibRecord, 004625

Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness

Identifieur interne : 004625 ( Main/Exploration ); précédent : 004624; suivant : 004626

Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness

Auteurs : Diego Garcia-Borreguero [Espagne] ; Ana B. Caminero [Espagne] ; Yolanda De La Llave [Espagne] ; Oscar Larrosa [Espagne] ; Soledad Barrio [Espagne] ; Juan J. Granizo [Espagne] ; Juan A. Pareja [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0585144

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Sommeil paradoxal, Electromyographie, Lévodopa, Antiparkinsonien, Chimiothérapie, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiparkinson agent, Chemotherapy, Electromyography, Exploration, Human, Levodopa, Parkinson disease, Rapid eye movement sleep.

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002606
to stream PascalFrancis, to step Curation: 000715
to stream PascalFrancis, to step Checkpoint: 002807
to stream Main, to step Merge: 006846
to stream Main, to step Curation: 004625

Le document en format XML

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<author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name>
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<front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness

Decreased phasic EMG activity during Rapid eye movement sleep in treatment-naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri